Marc Tjwa, MD PhD
Junior Group Leader since Jan 2008
2007, PhD, University of Leuven, Belgium
2000, MD, University of Leuven, Belgium

Office: +49-69-6301-7357
Lab: +49-69-6301-83978
Fax: +49-69-6301-7875
> E-mail > Curriculum Vitae

The independent Tjwa Laboratory (initiated in Jan 2008) is associated with the Centre for Molecular Medicine (formerly Dept. of Molecular Cardiology), which is directed by Professor Stefanie Dimmeler (see also in About us). Our Lab studies, via a complex biology approach, the regulation of hematopoietic stem cell (HSC) and cardio/vascular (stem/progenitor) cell fate. In particular, we investigate novel transcriptional, epigenetic, post-transcriptional and paracrine pathways, regulating the choice of HSCs to either undergo self-renewal or lineage commitment and differentiation, and how these pathways might contribute to leukemogenesis. In addition, in the context of angiogenesis and vascular biology research, we try to further unravel the (epi)genetic regulation of cardio/vascular (stem/progenitor) cells in response to tissue ischemia, inflammation, etc. These basic research studies are ultimately aimed at developing novel therapeutic targets for HSC expansion and transplantation, and the treatment of cardio/vascular diseases, leukemia and non-hematological malignancies.

Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher A, Dimmeler S.
MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice.
Science 2009;324:1710-3 ("exceptional (9.0)" in Faculty of 1000)

Tjwa M, Sidenius N, Moura R, Jansen S, Theunissen K, Andolfo A, De Mol M, Dewerchin M, Moons L, Blasi F, Verfaillie C, Carmeliet P.
Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment and mobilization of mouse hematopoietic stem/progenitor cells.
J Clin Invest 2009;119(4);1008-18 (highlighted in SciBX 2(11); doi:10.1038/scibx.2009.440)

Tjwa M, Moura R, Moons L, Plaisance S, De Mol M, Jansen S, Dewerchin M, Verfaillie C, Carmeliet P.
Fibrinolysis-independent role of plasmin and its activators in the hematopoietic recovery after myeloablation.
J Cell Mol Med 2009, DOI: 10.1111/j.1582-4934.2008.00521.x

Li X*, Tjwa M*, Fons P, Moons L, Noel A, Ny A, Zhou J, Lennartson J, Li H, Luttun A, Pontén A, Devy L, Bouché A, Oh H, Manderveld A, Blacher S, Savi P, Dewerchin M, Bono F, Foidart JM, Autiero M, Herbert J, Heldin C, Eriksson U, Carmeliet P. (*contributed equally).
Revascularization of ischemic tissues by PDGF-CC: effects on endothelial (progenitor) cells.
J Clin Invest 2005;115:118-27 (with comment in N Eng J Med, and "must read (6.0)" in Faculty of 1000)

Luttun A*, Tjwa M*, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy J, Hooper A, Priller J, De Klerck B, Compernolle V, Bohlen P, Dewerchin M, Herbert J, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak H, Hicklin D, Carmeliet P. (*contributed equally).
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt-1 antibody.
Nature Medicine 2002;8(8):831-40 (cover with News & Views; editorials in Nature Cancer Reviews, Nature)

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