Staff > Marc Tjwa

Curriculum Vitae of Marc Tjwa

Honors & Fellowships

2010, Invited Lecture at the Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis, Ventura, USA

2009, Invited oral short communication at the Keystone meeting "Cardiac Disease: Development, Regeneration, and Repair", Asheville, NC, USA

2008, Faculty Member of the ECCPS Excellence Cluster

2007, Keynote Lecture at the European Young Physiologists Symposium (Federation of European Physiological Societies, FEPS), Bratislava, Slovakia

2007-2010, Personal Research Fellowship: awarded by Belgian FWO

2006, Invited Lecture at the Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis, Ventura, USA

2000-2007, Personal Research Fellowships: awarded by Belgian IWT

Awards & Patents

11 Travel Awards, including Keystone (1x), ASH (2x), and ISEH (1x)

1 Patent Application: EP1667710, WO2005032572, CA2540529 – Means and methods for the recruitment and identification of stem cells – Inventors: Carmeliet P, Tjwa M – Assignees: VIB-DCRF – priority date: 03.10.2003; publication date: 14.04.2005

Memberships

American Society of Hematology (ASH; elected international member), American Heart Association (AHA), International Society for Stem Cell Research (ISSCR), International Society for Fibrinolysis & Proteolysis (ISPF), International Society for Experimental Hematology (ISEH), Belgian Society on Thrombosis and Haemostasis (BSTH), Belgian Society for Cell and Developmental Biology (BSCDB)

Teaching

2010 – now: PhD co-promotor of Anna Metodieva (Bulgaria), Goethe University Frankfurt, Germany (promotor: Martin Ruthardt (Frankfurt))

2009 – 2010: Co-supervisor of Lies De Groef (master student at the University of Leuven; together with Lieve Moons (Leuven)

2009 – now: Co-supervisor of Michael Fehrenbach (MD student at the Goethe University Frankfurt; together with Ingo Bechmann (Frankfurt/Leipzig)

2009 – now: PhD co-promotor of Tom Seijkens (Netherlands) on the project "Role of CD40L in hematopoiesis and atherosclerosis", University of Maastricht, Netherlands (promotor: Esther Lutgens (Maastricht))

2008 – now: "Regenerative Medicine: from bench to bedside" (Medical School & PhD training program), Goethe University Frankfurt, Germany

2008 – now: PhD mentor of Caroline Trouvain (Germany) on the project "Role of ACE in progenitor cell maintenance and mobilization", Goethe University Frankfurt, Germany (promotor: Ingrid Fleming (Frankfurt))

2006 - 2007: PhD mentor of Lola Bellido Martin (Spain) on the project "Role of Gas6 in inflammation and thrombosis", University of Leuven, Belgium (promotor: Pablo Garcia de Frutos (Barcelona); co-promotor: Lieve Moons (Leuven)); PhD obtained in 2007

2005 – 2007: "Functional genomics in small animal models for the identification of candidate disease genes" (3rd Bach, Faculty of Medicine), University of Leuven, Belgium

2003 – 2007: "Advanced Course in Laboratory Animal Science" (PhD training program), University of Leuven, Belgium

Ad Hoc Reviewer

Blood Journal, Circulation Research, Arteriosclerosis Thrombosis and Vascular Biology, European Heart Journal, FASEB Journal, Cardiovascular Research, Atherosclerosis, Am J Physiol Heart and Circulatory Physiology, Thrombosis and Haemostasis, Experimental Hematology, Stem Cells Dev, PLoS ONE, Life Sciences, Glia, Transplant Immunology, Neuroscience Letters, Pflugers Archiv – European Journal of Physiology; abstract reviewer for ISEH Annual Scientific Meeting; grant reviewer for University of Brussels, and the Dutch ZonMW.

Bibliography


	Citation Report per Year (Source: ISI Web of Knowledge^SM / Web of Science^®) Most recent update:

2010

Orlandi A, Chavakis E, Seeger F, Tjwa M, Zeiher A, Dimmeler S. Long-term diabetes impairs repopulation of hematopoietic progenitor cels and dysregulates the cytokine expression in the bone marrow microenvironment in mice. Basic Res Cardiol 2010; to be published

Moura R, Fadini GP, Tjwa M. Induced pluripotent stem (iPS) cells and endothelial cell generation: SIRT-ainly a good idea! Atherosclerosis 2010; doi: 10.1016/j.atherosclerosis.2010.06.031

Seijkens T, Engel D, Tjwa M, Lutgens E. The role of CD154 in hematopoietic development. Thromb Hemost 2010; to be published

Fadini GP, Tjwa M. A role for TGF-beta in transforming endothelial progenitor cells into neointimal smooth muscle cells. Atherosclerosis 2010;211(1):32-5

Loges S*, Schmidt T*, Tjwa M, Van Geyte K, Lievens D, Lutgens E, Vanhoutte D, Borgel D, Plaisance S, Hoylaerts M, Luttun A, Dewerchin M, Jonckx B, Carmeliet P (*equally contributed). Malignant cells fuel tumor growth by educating infiltrated leukocytes to produce the mitogen Gas6. Blood 2010;115:2264-73 ("recommended (3.0)" in Faculty of 1000)

Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann J, Tjwa M, Carmeliet P, Mandic V, David J, Behrens A, Nagy A, Carmeliet G, Haigh J. Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J 2010;29(2):424-41

2009

Tjwa M, Moura R, Moons L, Plaisance S, De Mol M, Jansen S, Dewerchin M, Verfaillie C, Carmeliet P. Fibrinolysis-independent role of plasmin and its activators in the hematopoietic recovery after myeloablation. J Cell Mol Med 2009;13:4587-95

Tjwa M, Moons L, Lutgens E. Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis. Curr Opin Lipidol. 2009;20(5):386-92

Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher A, Dimmeler S. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 2009;324:1710-3 ("exceptional (9.6)" in Faculty of 1000)

Tintu A, Rouwet E, Verlohren S, Brinkmann J, Ahmad S, Crispi F, Van Bilsen M, Carmeliet P, Staff AC, Tjwa M, Cetin I, Gratacos E, Hernandez-Andrade E, Hofstra L, Jacobs M, Lamers WH, Morano I, Safak E, Ahmed A, Le Noble F. Hypoxia Induces Dilated Cardiomyopathy in the Chick Embryo; Mechanism, Intervention, and Long-term Consequences. PLoS ONE 2009;4(4):e5155

Tjwa M, Sidenius N, Moura R, Jansen S, Theunissen K, Andolfo A, De Mol M, Dewerchin M, Moons L, Blasi F, Verfaillie C, Carmeliet P. Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment and mobilization of mouse hematopoietic stem/progenitor cells. J Clin Invest 2009;119(4);1008-18 (highlighted in SciBX 2(11); doi:10.1038/scibx.2009.440)

Tjwa M, Moons L, Verfaillie C, Carmeliet P. Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation. Blood 2009;113:1608-9

Feng Y, Van Eck M, Van Craeyveld E, Jacobs F, Carlier V, Van Linthout S, Erdel M, Tjwa M, De Geest B. Critical role of scavenger receptor-BI expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer. Blood 2009;113(3):755-64

2008

Dimmeler S, Tjwa M. Better regenerative output after cellular input: healing hearts by combining bFGF and cell-based therapy. J Am Coll Cardiol 2008;52:1866-8 (also in Highlights of 2008)

Moura R, Tjwa M, Vandervoort P, Vankerckhoven S, Holvoet P, Hoylaerts M. Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE deficient mice. Circ Res 2008;103:1181-89 (with editorial)

Tjwa M, Janssens S, Carmeliet P. Plasmin therapy enhances mobilization of HPCs after G-CSF. Blood 2008;112:4048-50

Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van den Bosch L, Meert T, D’Hooghe R, Sendtner M, Robberecht W, Carmeliet P. Novel role for VEGF-receptor-1 and its ligand VEGF-B in motor neuron degeneration. J Neuroscience 2008;28:10451-9

Tjwa M, Dimmeler S. A nucleolar weapon in our fight for regenerating adult hearts: nucleostemin and cardiac stem cells. Circ Res 2008;103:4-6

Li X*, Tjwa M*, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Diez-Juan T, Sievers R, Chorianopoulos E, Wada H, Vanwildermeersch M, Noel A, Foidart J, Springer M, Von Degenfeld G, Dewerchin M, Blau H, Alitalo K, Eriksson U, Carmeliet P, Moons L (*contributed equally). Re-evaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol 2008;28:1614-1620 (with editorial)

Lutgens E*, Tjwa M*, Garcia de Frutos P, Wijnands E, Beckers L, Dahlback B, Daemen M, Carmeliet P, Moons L (*contributed equally). Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol 2008;216:55-63

Vidal B*, Serrano A*, Tjwa M*, Suelves M, Ardite E, De Mori R, Baeza-Raja B, Martínez de Lagrán M, Lafuste P, Ruiz-Bonilla V, Jardi M, Gherardi R, Christov C, Dierssen M, Carmeliet P, Degen J, Dewerchin M, Muñoz-Cánoves P (*contributed equally). Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta / alternative macrophage activation pathway. Genes Dev 2008;22:1747-52 ("exceptional (9.0)" in Faculty of 1000)

Tjwa M, Bellido L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Herve C, Moura R, Billiau A, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert J, Waer M, García de Frutos P, Dahlbäck B, Carmeliet P, Hoylaerts M, Moons L. Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets and leukocytes. Blood 2008;111:4096-4105 (with editorial)

Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish R, Tjwa M, Plaisance S, Sugamele R, De Mol M, Martinez-Soria E, Flores N, Maxwell P, Lemke G, Goff S, Matsushima G, Earp H, Collen D, Izui S, Schapira M, Conway E, Carmeliet P. Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest 2008;118(2):583-96

Feng Y, Jacobs F, Van Craeyveld E, Brunaud C, Snoeys J, Tjwa M, Van Linthout S, De Geest B. Human apo A-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008;28(2):278-83

Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung N, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris B, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P. Deficiency or inhibition of the oxygen sensor PHD1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 2008;40(2):170-80 ("recommended (3.0)" in Faculty of 1000)

2007

Tirziu D, Chorianopoulos E, Moodie K, Palac R, Zhuang Z, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall A, Carmeliet P, Moons L, Simons M. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest 2007;117(11):3188-97 (with editorial)

Jost M, Maillard C, Lecompte J, Lambert V, Tjwa M, Blaise P, Alvarez Gonzalez M, Bajou K, Blacher S, Motte P, Humblet C, Defresne M, Thiry M, Frankenne F, Gothot A, Carmeliet P, Rakic J, Foidart J, Noël A. Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I (PAI-1). Am J Pathol 2007;171(4):1369-80

Moura R, Tjwa M, Vandervoort P, Cludts K, Hoylaerts M. Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation. Arterioscler Thromb Vasc Biol 2007;27(10):2163-9

Suelves M, Vidal B, Serrano A, Tjwa M, Roma J, López-Alemany R, Luttun A, Martínez de Lagrán M, Angels Diaz M, Jardí M, Roig M, Dierssen M, Dewerchin M, Carmeliet P, Muñoz-Cánoves P. uPA deficiency exacerbates muscular dystrophy in mdx mice. J Cell Biol 2007;178:1039-51

Umans L*, Cox L*, Tjwa M, Bito V, Vermeire L, Laperre K, Sipido K, Moons L, Huylebroeck D, Zwijsen A (*contributed equally). Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am J Pathol 2007;170:1460-72

2006

Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 2006;55:2698-2704

Vangheluwe P, Tjwa M, Van den Bergh A, Louch W, Beullens M, Dode L, Carmeliet P, Kranias E, Herijgers P, Sipido K, Raeymaekers L, Wuytack F. A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span. J Mol Cell Cardiol 2006;41(2):308-17

Tjwa M, Carmeliet P, Moons L. A novel transgenic rabbit model sheds light on the puzzling role of MMP-12 in atherosclerosis. Circulation 2006;113:1929-32

2005

Schneider M, Tjwa M, Carmeliet P. A surrogate marker to monitor angiogenesis at last. Cancer Cell 2005;7(1):3-4

Acker T*, Diez-Juan A*, Aragones J*, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano M, Herbert J, Burger A, Riedel J, Elvert G, Flamme I, Maxwell P, Collen D, Dewerchin M, Jain R, Plate K, Carmeliet P (*contributed equally). Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 2005;8(2):131-41 ("must read (6.0)" in Faculty of 1000)

Li X*, Tjwa M*, Fons P, Moons L, Noel A, Ny A, Zhou J, Lennartson J, Li H, Luttun A, Pontén A, Devy L, Bouché A, Oh H, Manderveld A, Blacher S, Savi P, Dewerchin M, Bono F, Foidart J, Autiero M, Herbert JM, Heldin C, Eriksson U, Carmeliet P (*contributed equally). Revascularization of ischemic tissues by PDGF-CC: effects on endothelial (progenitor) cells. J Clin Invest 2005;115:118-27 (with comment in N Eng J Med, and "must read (6.0)" in Faculty of 1000))

2004

Luttun A, Autiero M, Tjwa M, Carmeliet P. Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets? Biochim Biophys Acta 2004;1654(1):79-94

Luttun A*, Tjwa M* and Carmeliet P (*contributed equally). The formation of blood and lymphatic vessels: role of progenitors. In: Handbook of Stem Cells 2004;2:455-74. Edited by Weissman I, Melton D, Verfaillie C, Moore M, Blau H, West M and Lanza R.

Janssens S, Pokreisz P, Schoonjans L, Pellens M, Vermeersch P, Tjwa M, Jans P, Scherrer-Crosbie M, Picard M, Szelid Z, Gillijns H, Van de Werf F, Collen D, Bloch K. Cardiomyocyte-specific overexpression of Nitric Oxide Synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial Infarction. Circ Res 2004;94:1256-62

Molinas C, Tjwa M, Vanacker B, Binda M, Elkelani O, Koninckx P. Role of CO2 pneumoperitoneum-induced acidosis in CO2 pneumoperitoneum-enhanced adhesion formation in mice. Fertil Steril 2004;81(3):708-11

2003

Brusselmans K, Compernolle V, Tjwa M, Wiesener M, Maxwell P, D Collen, Carmeliet P. Heterozygous deficiency of the hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 2003;111:1519-27

Tjwa M, Luttun A, Autiero M, Carmeliet P. VEGF and PlGF: two pleitropic growth factors with distinct roles in development and homeostasis. Cell Tissue Res 2003;314(1):5-14

Autiero M, Luttun A, Tjwa M, Carmeliet P. PlGF and its receptor VEGFR-1 (Flt1): novel targets to stimulate ischemic tissue revascularization and inhibit angiogenic and inflammatory disorders. J Thromb Haemost 2003;1:1356-70 (awarded with J Thromb Haemost Picture Prize 2003).

2002

Luttun A, Tjwa M, Carmeliet P. Placental Growth Factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. Ann NY Acad Sci USA 2002;979:80-93

Luttun A, Brusselmans K, Fukao H, Tjwa M, Ueshima S, Herbert J, Matsuo O, Collen D, Carmeliet P, Moons L. Loss of Placental Growth Factor (PlGF) protects mice against vascular permeability in pathological conditions. Biochem Biophys Res Commun 2002;295:428-34

Luttun A*, Tjwa M*, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy J, Hooper A, Priller J, De Klerck B, Compernolle V, Bohlen P, Dewerchin M, Herbert J, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak H, Hicklin D, Carmeliet P (*contributed equally). Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt-1 antibody. Nature Medicine 2002;8(8):831-40 (cover with News & Views; editorials in Nature Cancer Reviews, Nature)

Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nature Medicine 2002;8(7):702-10 (with News & Views)

2001

Tjwa M, De Hertogh G, Neuville B, Roskams T, Nevens F, Van Steenbergen W. Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature. Acta Clinica Belgica 2001;56(6):341-8

Tjwa M, Verhoef G. Thrombotic Thrombocytopenic Purpura: Case Report and review of the literature. Tijdschrift voor Geneeskunde 2001; 57(9): 674-81.

Honors & Fellowships

Awards & Patents

Memberships

Teaching

Ad Hoc Reviewer

Bibliography

Citation Report per Year (Source: ISI Web of Knowledge^SM / Web of Science^®)
Most recent update:

Orlandi A, Chavakis E, Seeger F, Tjwa M, Zeiher A, Dimmeler S. Long-term diabetes impairs repopulation of hematopoietic progenitor cels and dysregulates the cytokine expression in the bone marrow microenvironment in mice. Basic Res Cardiol 2010; to be published

Moura R, Fadini GP, Tjwa M. Induced pluripotent stem (iPS) cells and endothelial cell generation: SIRT-ainly a good idea! Atherosclerosis 2010; doi: 10.1016/j.atherosclerosis.2010.06.031

Seijkens T, Engel D, Tjwa M, Lutgens E. The role of CD154 in hematopoietic development. Thromb Hemost 2010; to be published

Fadini GP, Tjwa M. A role for TGF-beta in transforming endothelial progenitor cells into neointimal smooth muscle cells. Atherosclerosis 2010;211(1):32-5

Tjwa M, Moura R, Moons L, Plaisance S, De Mol M, Jansen S, Dewerchin M, Verfaillie C, Carmeliet P. Fibrinolysis-independent role of plasmin and its activators in the hematopoietic recovery after myeloablation. J Cell Mol Med 2009;13:4587-95

Tjwa M, Moons L, Lutgens E. Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis. Curr Opin Lipidol. 2009;20(5):386-92

Tjwa M, Moons L, Verfaillie C, Carmeliet P. Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation. Blood 2009;113:1608-9

Feng Y, Van Eck M, Van Craeyveld E, Jacobs F, Carlier V, Van Linthout S, Erdel M, Tjwa M, De Geest B. Critical role of scavenger receptor-BI expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo A-I transfer. Blood 2009;113(3):755-64

Dimmeler S, Tjwa M. Better regenerative output after cellular input: healing hearts by combining bFGF and cell-based therapy. J Am Coll Cardiol 2008;52:1866-8 (also in Highlights of 2008)

Moura R, Tjwa M, Vandervoort P, Vankerckhoven S, Holvoet P, Hoylaerts M. Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE deficient mice. Circ Res 2008;103:1181-89 (with editorial)

Tjwa M, Janssens S, Carmeliet P. Plasmin therapy enhances mobilization of HPCs after G-CSF. Blood 2008;112:4048-50

Tjwa M, Dimmeler S. A nucleolar weapon in our fight for regenerating adult hearts: nucleostemin and cardiac stem cells. Circ Res 2008;103:4-6

Lutgens E, Tjwa M, Garcia de Frutos P, Wijnands E, Beckers L, Dahlback B, Daemen M, Carmeliet P, Moons L (contributed equally).* Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol 2008;216:55-63

Feng Y, Jacobs F, Van Craeyveld E, Brunaud C, Snoeys J, Tjwa M, Van Linthout S, De Geest B. Human apo A-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008;28(2):278-83

Tirziu D, Chorianopoulos E, Moodie K, Palac R, Zhuang Z, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall A, Carmeliet P, Moons L, Simons M. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest 2007;117(11):3188-97 (with editorial)

Moura R, Tjwa M, Vandervoort P, Cludts K, Hoylaerts M. Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation. Arterioscler Thromb Vasc Biol 2007;27(10):2163-9

Suelves M, Vidal B, Serrano A, Tjwa M, Roma J, López-Alemany R, Luttun A, Martínez de Lagrán M, Angels Diaz M, Jardí M, Roig M, Dierssen M, Dewerchin M, Carmeliet P, Muñoz-Cánoves P. **uPA deficiency exacerbates muscular dystrophy in mdx mice.** J Cell Biol 2007;178:1039-51

Umans L, Cox L, Tjwa M, Bito V, Vermeire L, Laperre K, Sipido K, Moons L, Huylebroeck D, Zwijsen A *(contributed equally). Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am J Pathol 2007;170:1460-72

Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 2006;55:2698-2704

Tjwa M, Carmeliet P, Moons L. A novel transgenic rabbit model sheds light on the puzzling role of MMP-12 in atherosclerosis. Circulation 2006;113:1929-32

Schneider M, Tjwa M, Carmeliet P. A surrogate marker to monitor angiogenesis at last. Cancer Cell 2005;7(1):3-4

Luttun A, Autiero M, Tjwa M, Carmeliet P. Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets? Biochim Biophys Acta 2004;1654(1):79-94

Luttun A, Tjwa M* and Carmeliet P (contributed equally). The formation of blood and lymphatic vessels: role of progenitors. In: Handbook of Stem Cells 2004;2:455-74. Edited by Weissman I, Melton D, Verfaillie C, Moore M, Blau H, West M and Lanza R.

Molinas C, Tjwa M, Vanacker B, Binda M, Elkelani O, Koninckx P. Role of CO2 pneumoperitoneum-induced acidosis in CO2 pneumoperitoneum-enhanced adhesion formation in mice. Fertil Steril 2004;81(3):708-11

Brusselmans K, Compernolle V, Tjwa M, Wiesener M, Maxwell P, D Collen, Carmeliet P. Heterozygous deficiency of the hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 2003;111:1519-27

Tjwa M, Luttun A, Autiero M, Carmeliet P. VEGF and PlGF: two pleitropic growth factors with distinct roles in development and homeostasis. Cell Tissue Res 2003;314(1):5-14

Autiero M, Luttun A, Tjwa M, Carmeliet P. PlGF and its receptor VEGFR-1 (Flt1): novel targets to stimulate ischemic tissue revascularization and inhibit angiogenic and inflammatory disorders. J Thromb Haemost 2003;1:1356-70 (awarded with J Thromb Haemost Picture Prize 2003).

Luttun A, Tjwa M, Carmeliet P. Placental Growth Factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. Ann NY Acad Sci USA 2002;979:80-93

Luttun A, Brusselmans K, Fukao H, Tjwa M, Ueshima S, Herbert J, Matsuo O, Collen D, Carmeliet P, Moons L. Loss of Placental Growth Factor (PlGF) protects mice against vascular permeability in pathological conditions. Biochem Biophys Res Commun 2002;295:428-34

Tjwa M, De Hertogh G, Neuville B, Roskams T, Nevens F, Van Steenbergen W. Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature. Acta Clinica Belgica 2001;56(6):341-8

Tjwa M, Verhoef G. Thrombotic Thrombocytopenic Purpura: Case Report and review of the literature. Tijdschrift voor Geneeskunde 2001; 57(9): 674-81.

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Honors & Fellowships

Awards & Patents

Memberships

Teaching

Ad Hoc Reviewer

Bibliography

Orlandi A, Chavakis E, Seeger F, Tjwa M, Zeiher A, Dimmeler S. Long-term diabetes impairs repopulation of hematopoietic progenitor cels and dysregulates the cytokine expression in the bone marrow microenvironment in mice. Basic Res Cardiol 2010; to be published

Moura R, Fadini GP, Tjwa M. Induced pluripotent stem (iPS) cells and endothelial cell generation: SIRT-ainly a good idea! Atherosclerosis 2010; doi: 10.1016/j.atherosclerosis.2010.06.031

Seijkens T, Engel D, Tjwa M, Lutgens E. The role of CD154 in hematopoietic development. Thromb Hemost 2010; to be published

Fadini GP, Tjwa M. A role for TGF-beta in transforming endothelial progenitor cells into neointimal smooth muscle cells. Atherosclerosis 2010;211(1):32-5

Tjwa M, Moura R, Moons L, Plaisance S, De Mol M, Jansen S, Dewerchin M, Verfaillie C, Carmeliet P. Fibrinolysis-independent role of plasmin and its activators in the hematopoietic recovery after myeloablation. J Cell Mol Med 2009;13:4587-95

Tjwa M, Moons L, Lutgens E. Pleiotropic role of growth arrest-specific gene 6 in atherosclerosis. Curr Opin Lipidol. 2009;20(5):386-92

Tjwa M, Moons L, Verfaillie C, Carmeliet P. Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation. Blood 2009;113:1608-9

Dimmeler S, Tjwa M. Better regenerative output after cellular input: healing hearts by combining bFGF and cell-based therapy. J Am Coll Cardiol 2008;52:1866-8 (also in Highlights of 2008)

Moura R, Tjwa M, Vandervoort P, Vankerckhoven S, Holvoet P, Hoylaerts M. Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE deficient mice. Circ Res 2008;103:1181-89 (with editorial)

Tjwa M, Janssens S, Carmeliet P. Plasmin therapy enhances mobilization of HPCs after G-CSF. Blood 2008;112:4048-50

Tjwa M, Dimmeler S. A nucleolar weapon in our fight for regenerating adult hearts: nucleostemin and cardiac stem cells. Circ Res 2008;103:4-6

Lutgens E*, Tjwa M*, Garcia de Frutos P, Wijnands E, Beckers L, Dahlback B, Daemen M, Carmeliet P, Moons L (*contributed equally). Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol 2008;216:55-63

Feng Y, Jacobs F, Van Craeyveld E, Brunaud C, Snoeys J, Tjwa M, Van Linthout S, De Geest B. Human apo A-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008;28(2):278-83

Tirziu D, Chorianopoulos E, Moodie K, Palac R, Zhuang Z, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall A, Carmeliet P, Moons L, Simons M. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest 2007;117(11):3188-97 (with editorial)

Moura R, Tjwa M, Vandervoort P, Cludts K, Hoylaerts M. Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation. Arterioscler Thromb Vasc Biol 2007;27(10):2163-9

Suelves M, Vidal B, Serrano A, Tjwa M, Roma J, López-Alemany R, Luttun A, Martínez de Lagrán M, Angels Diaz M, Jardí M, Roig M, Dierssen M, Dewerchin M, Carmeliet P, Muñoz-Cánoves P. uPA deficiency exacerbates muscular dystrophy in mdx mice. J Cell Biol 2007;178:1039-51

Umans L*, Cox L*, Tjwa M, Bito V, Vermeire L, Laperre K, Sipido K, Moons L, Huylebroeck D, Zwijsen A (*contributed equally). Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am J Pathol 2007;170:1460-72

Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 2006;55:2698-2704

Tjwa M, Carmeliet P, Moons L. A novel transgenic rabbit model sheds light on the puzzling role of MMP-12 in atherosclerosis. Circulation 2006;113:1929-32

Schneider M, Tjwa M, Carmeliet P. A surrogate marker to monitor angiogenesis at last. Cancer Cell 2005;7(1):3-4

Luttun A, Autiero M, Tjwa M, Carmeliet P. Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets? Biochim Biophys Acta 2004;1654(1):79-94

Luttun A*, Tjwa M* and Carmeliet P (*contributed equally). The formation of blood and lymphatic vessels: role of progenitors. In: Handbook of Stem Cells 2004;2:455-74. Edited by Weissman I, Melton D, Verfaillie C, Moore M, Blau H, West M and Lanza R.

Molinas C, Tjwa M, Vanacker B, Binda M, Elkelani O, Koninckx P. Role of CO2 pneumoperitoneum-induced acidosis in CO2 pneumoperitoneum-enhanced adhesion formation in mice. Fertil Steril 2004;81(3):708-11

Brusselmans K, Compernolle V, Tjwa M, Wiesener M, Maxwell P, D Collen, Carmeliet P. Heterozygous deficiency of the hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 2003;111:1519-27

Tjwa M, Luttun A, Autiero M, Carmeliet P. VEGF and PlGF: two pleitropic growth factors with distinct roles in development and homeostasis. Cell Tissue Res 2003;314(1):5-14

Autiero M, Luttun A, Tjwa M, Carmeliet P. PlGF and its receptor VEGFR-1 (Flt1): novel targets to stimulate ischemic tissue revascularization and inhibit angiogenic and inflammatory disorders. J Thromb Haemost 2003;1:1356-70 (awarded with J Thromb Haemost Picture Prize 2003).

Luttun A, Tjwa M, Carmeliet P. Placental Growth Factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. Ann NY Acad Sci USA 2002;979:80-93

Luttun A, Brusselmans K, Fukao H, Tjwa M, Ueshima S, Herbert J, Matsuo O, Collen D, Carmeliet P, Moons L. Loss of Placental Growth Factor (PlGF) protects mice against vascular permeability in pathological conditions. Biochem Biophys Res Commun 2002;295:428-34

Tjwa M, De Hertogh G, Neuville B, Roskams T, Nevens F, Van Steenbergen W. Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature. Acta Clinica Belgica 2001;56(6):341-8

Tjwa M, Verhoef G. Thrombotic Thrombocytopenic Purpura: Case Report and review of the literature. Tijdschrift voor Geneeskunde 2001; 57(9): 674-81.

Lutgens E, Tjwa M, Garcia de Frutos P, Wijnands E, Beckers L, Dahlback B, Daemen M, Carmeliet P, Moons L (contributed equally).* Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol 2008;216:55-63

Suelves M, Vidal B, Serrano A, Tjwa M, Roma J, López-Alemany R, Luttun A, Martínez de Lagrán M, Angels Diaz M, Jardí M, Roig M, Dierssen M, Dewerchin M, Carmeliet P, Muñoz-Cánoves P. **uPA deficiency exacerbates muscular dystrophy in mdx mice.** J Cell Biol 2007;178:1039-51

Umans L, Cox L, Tjwa M, Bito V, Vermeire L, Laperre K, Sipido K, Moons L, Huylebroeck D, Zwijsen A *(contributed equally). Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am J Pathol 2007;170:1460-72

Luttun A, Tjwa M* and Carmeliet P (contributed equally). The formation of blood and lymphatic vessels: role of progenitors. In: Handbook of Stem Cells 2004;2:455-74. Edited by Weissman I, Melton D, Verfaillie C, Moore M, Blau H, West M and Lanza R.